The Newton family live in their comfortable house, but there appears to be something. This"hole" is filled by a little puppy, that walks into their own home and their lifestyles. Beethoven, because he could be termed, grows to a giant of a dog... a St Bernard. The vet, Physician Varnick comes with a dreadful and secret side-line, which requires a lot of dogs for experiments. Beethoven is really on the list of the doctor.