Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a bag full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the duo that is benign fear repercussions and garbage their accommodation. Duke begins to drive straight back again to L.A., but after a strange runin with a cop, he also returns to Sin City and continues his own uncontrolled drug binge.