The Cassandra Crossing is an disaster notification that is spectacular of those terrifying odyssey of all 1000 passengers trapped aboard an train that is plague-infested. A terrorist exposes into the disorder and infected that the Stockholm into Geneva Express. Colonel Mackenzie (Burt Lancaster) is called in to take care of the problem and locates Dr. Chamberlain (Richard Harris) who's on board the train. At which it'll dive into oblivion, mackenzie decides to reroute the train into the Cassandra Crossing. But passengers begin to recuperate and Chamberlain must race against time to disconnect the cars.