The use of drugs in Rome is at an all-time high. Interpol's Mike Hamilton (David Hemmings) is at his wits' end as schoolchildren buy drugs from dealers and mules breeze through airport security. Fed up with the local police force's inefficiency, Hamilton's last hope is one of his own men, Fabio (Fabio Testi), a deep undercover cop only Hamilton knows. Fabio gains the trust of cartel leader Gianni (John Loffredo), but when his cover is revealed, he becomes the hunted and must battle to survive.